Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1171 | Obesity | ICEECE2012

Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

Martinez de Morentin P. , Whittle A. , Martinez-Sanchez N. , Martins L. , Ferno J. , Nogueiras R. , Dieguez C. , Vidal-Puig A. , Lopez M.

Introduction: Smokers around the globe commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. In addition, numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. Nicotine’s effects on energy homeostasis have been mostly pinpointed in the central nervous system, but the molecular mechanisms controlling its action are still not fully understood...